United States securities and exchange commission logo

                          July 2, 2020

       Praveen P. Tipirneni, M.D.
       President and Chief Executive Officer
       Morphic Holding, Inc.
       35 Gatehouse Drive, A2
       Waltham, MA 02451

                                                        Re: Morphic Holding,
Statement on Form S-3
                                                            Filed July 1, 2020
                                                            File No. 333-239607

       Dear Dr. Tipirneni:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Tim
Buchmiller at (202) 551-3635 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Julia Forbess, Esq.