Washington, D.C. 20549


Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB Number: 3235-0104
Estimated average burden
hours per response: 0.5
1. Name and Address of Reporting Person*
Tipirneni Praveen P.

(Last) (First) (Middle)


(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
3. Issuer Name and Ticker or Trading Symbol
Morphic Holding, Inc. [ MORF ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director 10% Owner
X Officer (give title below) Other (specify below)
President and CEO
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock 630,916(1) I By The Praveen P. Tipirneni Irrevocable Trust of 2019(2)
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Series Seed Preferred Stock (3) (3) Common Stock 45,558 (3) I By The Praveen P. Tipirneni Irrevocable Trust of 2019(2)
Stock Option (right to buy Common Stock) (4) 12/14/2028 Common Stock 463,458 4.32 D
Explanation of Responses:
1. Certain of the shares are subject to the issuer's right of repurchase if underlying vesting conditions are not met.
2. These securities are held of record by Sonali N. Shah, Trustee of The Praveen P. Tipirneni Irrevocable Trust of 2019. The reporting person disclaims beneficial ownership of the shares except to the extent of his pecuniary interest therein.
3. Each share of the issuer's Series Seed Preferred Stock will automatically convert into one share of the issuer's Common Stock immediately upon the closing of the issuer's initial public offering and has no expiration date.
4. The option vests as to 2.0833% of the total shares monthly, beginning January 14, 2019, with 100% of the total shares vested and exercisable on December 14, 2022, subject to the reporting person's provision of service to the issuer on each vesting date.
/s/ Robert Farrell as attorney-in-fact for Praveen P. Tipirneni 06/26/2019
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
                           LIMITED POWER OF ATTORNEY

      The  undersigned  hereby  constitutes and appoints Robert Farrell, William
DeVaul  and Praveen Tipirneni, as long as they are providing services to Morphic
Holding,  Inc.,  a  Delaware  corporation  (the  "Company"), or any of them, the
undersigned's true and lawful attorney-in-fact to:

      (1)   execute  for  and on behalf of the undersigned, in the undersigned's
            capacity  as  an  officer and/or director of the Company, Forms 3, 4
            and  5  in  accordance with Section 16(a) of the Securities Exchange
            Act  of  1934,  as  amended  (the "Exchange Act"), and the rules and
            regulations thereunder;

      (2)   do and perform any and all acts for and on behalf of the undersigned
            that  may be necessary or desirable to complete and execute any such
            Forms  3,  4s  and 5s and timely file such forms with the Securities
            and Exchange Commission and any stock exchange or similar authority,
            if required; and

      (3)   take  any other action of any type whatsoever in connection with the
            foregoing  that,  in the opinion of such attorney-in-fact, may be of
            benefit  to,  in  the  best interest of, or legally required by, the
            undersigned, it being understood that the documents executed by such
            attorney-in-fact on behalf of the undersigned pursuant to this Power
            of  Attorney  shall be in such form and shall contain such terms and
            conditions   as   such   attorney-in-fact   may   approve   in  such
            attorney-in-fact's discretion.

      The undersigned hereby grants to each such attorney-in-fact full power and
authority  to  do and perform each and every act and thing whatsoever requisite,
necessary  or  proper to be done in the exercise of any of the rights and powers
herein granted, as fully to all intents and purposes as the undersigned might or
could  do if personally present, with full power of substitution and revocation,
hereby  ratifying  and  confirming  all that each such attorney-in-fact, or each
such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to
be  done  by  virtue  of this power of attorney and the rights and powers herein
granted.   The   undersigned   acknowledges   that   each   of   the   foregoing
attorneys-in-fact,   in   serving  in  such  capacity  at  the  request  of  the
undersigned,  is  not  assuming,  nor  is  the  Company  assuming,  any  of  the
undersigned's responsibilities to comply with Section 16 of the Exchange Act.

      The  undersigned  agrees that each such attorney-in-fact may rely entirely
on  information  furnished  orally or in writing by the undersigned to each such
attorney-in-fact. The undersigned also agrees to indemnify and hold harmless the
Company  and  each  such attorney-in-fact against any losses, claims, damages or
liabilities (or actions in these respects) that arise out of or are based on any
untrue  statement  or omission of necessary facts in the information provided by
the   undersigned   to   such   attorney-in-fact   for  purposes  of  executing,
acknowledging,  delivering  and  filing  Forms  3,  4 or 5 (including amendments
thereto)  and agrees to reimburse the Company and each such attorney-in-fact for
any legal or other expenses reasonably incurred in connection with investigating
or defending against any such loss, claim, damage, liability or action.

      This  Power  of  Attorney  shall remain in full force and effect until the
undersigned  is  no longer required to file Forms 3, 4 and 5 with respect to the
undersigned's  holdings of and transactions in securities issued by the Company,
unless  earlier  revoked by the undersigned in a signed writing delivered to the
foregoing attorneys-in-fact.

      IN  WITNESS  WHEREOF, the undersigned has caused this Power of Attorney to
be executed as of this 19 day of June 2019.

                                                     /s/ Praveen P. Tipirneni
                                                     Name:  Praveen P. Tipirneni